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Collaboration across disciplines has also been necessary, involving clinician investigators for detailed clinical phenotyping, geneticists, molecular biologists, and latterly informatics experts able to handle huge databases integrating a wealth of information from different sources. This work has required a change of attitude and approach by investigators collaboration between many groups of investigators, sometimes on a global scale, has been necessary to build cohorts sufficiently large to be robustly informative. It was an exciting time to be in diabetes.Since that first clinical description of a subtype of diabetes, advances in technologies in genetics, molecular biomarkers and ‘omics’ have revealed much about the pathophysiology and natural history of diabetes and individual responses to glucose-lowering therapies. This, he said, “may go some way to explaining my interest in the psychological aspects of diabetes and the hinterland between medicine and psychiatry.” He studied at Cambridge and St Thomas’ Hospital and did a senior house officer job at Nottingham General Hospital before joining David Pyke in London. Robert was born to two psychiatrists and went on to marry one. It opened up a whole new field of research, which continues to yield a dividend both for science and for those who carry the genes involved. This simple clinical observation and some intensive sleuth work led to the discovery of maturity onset diabetes of the young (MODY), the first single gene variant of diabetes to be described. David Pyke-Robert’s mentor-recalled the same phenomenon in another family.

The young Robert Tattersall was working on a study of long term diabetes at King’s College London, when he came across a woman with a 40 year history of diabetes who had stopped taking insulin.